A big congratulations to Ben for his recent paper describing our initial efforts at engineering the RNA-directed DNA nuclease Cas9. This paper describes some of Ben's initial work at constructing genetic screens to interrogate and engineer Cas9 function. Hopefully this will be the start of many interesting things to come!
Oakes, B. L., Nadler, D. C., & Savage, D. F. (2014). Protein engineering of Cas9 for enhanced function. Methods in Enzymology, 546, 491–511. doi:10.1016/B978-0-12-801185-0.00024-6